Endocrine Abstracts

Osteoporosis is a polygenic disease. The intensive search for genetic markers has led to the identification of several genetic polymorphisms, associated with the decrease of bone tissue and therefore a higher risk of osteoporosis.The study aimed to evaluate estrogen receptor alpha (ESR1) and vitamin D receptor (VDR) polymorphisms in postmenopausal women with or without osteoporosis and their correlations with bone markers and adipocytokines.<p class=...

Introduction: Sarcoidosis is a multisystemic inflammatory disease of unknown etiology, characterized by noncaseating granulomas, predominantly in the lymph nodes, lungs, eyes and skin, although any organ may be involved.Sarcoidosis may also be associated with endocrine autoimmune diseases such as type 1 diabetes, autoimmune thyroiditis.Case report: We present a case of a 24-year-old young man who was diagnosed in August 2010 with t...

The nitrogen-containing bisphosphonate Risedronate have been shown to reduce the risk of both spine and nonspine fractures by reducing bone turnover, increasing bone mass and improving bone strength.Objective: To study the effects of once-weekly Risedronate on bone turnover markers in osteoporotic patients after three month of treatment.Patients and methods: Study group included 50 osteoporotic patients (3 males and 47 females), me...

The nitrogen-containing bisphosphonate Risedronate have been shown to reduce the risk of both spine and nonspine fractures by reducing bone turnover, increasing bone mass and improving bone strength.Objective: To study the effects of once-weekly Risedronate on bone turnover markers in osteoporotic patients after three month of treatment.Patients and methods: Study group included 50 osteoporotic patients (3 males and 47 females), me...

Insulin resistance is possibly playing an underlying pathogenic role in the polycystic ovary syndrome (PCOS) and although is not a part of its definition, it appears in 50-90% of PCOS women. Polycystic ovary syndrome is also frequently associated with obesity; women suffering of PCOS seem to be at a great risk of developing a metabolic syndrome.Objectives: The aim of our study was to determine the prevalence of the metabolic syndrome in a population of 4...

Background data: Laparoscopic adrenalectomy has became in the last decade “gold standard” for treating of adrenal tumors with diameters smaller than six cm. In addition, one should note than larger tumors or potentially malignant tumors can now also be removed laparoscopically, with virtually no complication.Objective: The authors evaluate the effectiveness of laparoscopic adrenalectomy for a large adrenal tumors.Methods:...

Human adipose tissue provides abundant source of mesenchymal stem cells, which can be easily and safely harvested as compared with human bone marrow.The aim of this study was to differentiate a viable osteoblast and adipocyte cell culture from mesenchymal stem cells, an experimental model to study the interrelation between adipocytes and bone forming cells, osteoblasts.Materials and methods: Subcutaneous adipose tissue liposuction ...

Introduction: Tuberculosis is an insidious disease and may be diagnosed after it afected many organs.Case presentation: We present the case of a 56 years old female, who followed antituberculosis treatment in 2003 for pulmonary tuberculosis and during the treatment developed acute renal failure and for this reason the treatment was stopped. During the evaluations a left kidney tumor was detected. Left nephrectomy was performed in 2003 (HP examination &#1...

The physiological and neuroendocrine functions of the pineal gland hormone, melatonin and its therapeutic potential critically depend on the understanding of its target sites and its mechanism of action. There is evidence that melatonin promoted osteoblast differentiation and mineralization in MC3T3-E1 (mouse preosteoblast) and rat osteoblast-like osteosarcoma 17/2.8 cells. Our group set up an experimental model of mouse osteoblast culture. As a marker specific for osteoblast ...

Disruption of the normal cell cycle is one of the most frequent alterations in tumour cells, contributing to uncontrolled cell proliferation during tumour development. The CDK inhibitor p27 plays a pivotal role in controlling cell proliferation during development and tumourigenesis, and has been implicated in tumorigenesis in rats. Previous studies have demonstrated changes in p27 protein expression, in human pituitary tumours,especially in corticotroph tumours, where p27 prot...